The TotalEnergies CAF Africa Cup of Nations (AFCON) 2025 has reached the knockout stage, with mouth-watering Round of 16 fixtures confirmed as Africa’s finest teams battle for a place in the quarter-finals.

West African giants Mali will face a stern test against Tunisia in what promises to be a tightly contested opener, while tournament hosts Morocco take on Tanzania, hoping home support will drive them deeper into the competition.

Algeria are set for a physical encounter against DR Congo, as both sides look to assert dominance in a clash of continental heavyweights. Egypt, seven-time AFCON champions, will square off against Benin, with the Pharaohs aiming to maintain their strong knockout pedigree.

Defending champions Senegal meet Sudan in a tie that pits experience against resilience, while Nigeria’s Super Eagles will lock horns with Mozambique, seeking to convert their group-stage momentum into a quarter-final berth.

Another blockbuster fixture sees South Africa take on Cameroon in a classic duel of AFCON pedigree, while Burkina Faso face Côte d’Ivoire in an all-West African contest that could go down to fine margins.

With no second chances at this stage, the Round of 16 promises high drama, tactical battles, and moments of individual brilliance as the race for the AFCON 2025 title intensifies across host venues.